TLR3 polyclonal antibody
产品名称： TLR3 polyclonal antibody
英文名称： TLR3 polyclonal antibody
产品编号： PAB9728
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TLR3.
- Immunogen:
- A synthetic peptide corresponding to C-terminus of human TLR3.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus.
Guillot L, Le Goffic R, Bloch S, Escriou N, Akira S, Chignard M, Si-Tahar M.J Biol Chem. 2005 Feb 18;280(7):5571-80. Epub 2004 Dec 3.
- 2.
- Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis.
Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA.Nat Med. 2004 Dec;10(12):1366-73. Epub 2004 Nov 21.
- Entrez GeneID:
- 7098
- Gene Name:
- TLR3
- Gene Alias:
- CD283
- Gene Description:
- toll-like receptor 3
- Omim ID:
- 603029
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq
- Other Designations:
- -
- Gene Pathway
- Related Disease
- Arthritis, Rheumatoid
- Aspergillosis
- Asthma
- Asthma
- Birth Weight
- Breast Neoplasms
- Bronchiolitis Obliterans
- Bronchiolitis, Viral
- Cardiomyopathy, Dilated
- Cardiovascular Diseases
- Chorioamnionitis
- Choroidal Neovascularization
- Chronic Disease
- Connective Tissue Diseases
- Coxsackievirus Infections
- Diabetes Mellitus, Type 1
- Disease Progression
- Epidermal Necrolysis, Toxic
- Eye Diseases