APAF1 polyclonal antibody
产品名称: APAF1 polyclonal antibody
英文名称: APAF1 polyclonal antibody
产品编号: PAB9764
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of APAF1.
- Immunogen:
- A synthetic peptide corresponding to amino acids 1158-1177 of Human APAF1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
Cecconi F, Alvarez-Bolado G, Meyer BI, Roth KA, Gruss P.Cell. 1998 Sep 18;94(6):727-37.
- 2.
- Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation.
Hu Y, Benedict MA, Wu D, Inohara N, Nunez G.Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4386-91.
- 3.
- Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X.Cell. 1997 Nov 14;91(4):479-89.
- Entrez GeneID:
- 317
- Gene Name:
- APAF1
- Gene Alias:
- CED4,DKFZp781B1145
- Gene Description:
- apoptotic peptidase activating factor 1
- Omim ID:
- 602233
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq
- Other Designations:
- apoptotic protease activating factor 1
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