ENG monoclonal antibody, clone SN6/N1-3A1
产品名称： ENG monoclonal antibody, clone SN6/N1-3A1
英文名称： ENG monoclonal antibody, clone SN6/N1-3A1
产品编号： MAB6928
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native ENG.
- Immunogen:
- Native purified ENG from human B-lineage leukemia cells.
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- Antibody SN6 will augment binding of TGF-b1 to CD105 expressing leukemia cells.
- Form:
- Liquid
- Isotype:
- IgG1, kappa
- Storage Buffer:
- In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
- Storage Instruction:
- Store at 4°C.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.
Cheifetz S, Bellon T, Cales C, Vera S, Bernabeu C, Massague J, Letarte M.J Biol Chem. 1992 Sep 25;267(27):19027-30.
- 2.
- Efficient transplantation of human non-T-leukemia cells into nude mice and induction of complete regression of the transplanted distinct tumors by ricin A-chain conjugates of monoclonal antibodies SN5 and SN6.
Hara H, Luo Y, Haruta Y, Seon BK.Cancer Res. 1988 Aug 15;48(16):4673-80.
- Application Image
- Immunohistochemistry (Frozen sections)
- Immunoprecipitation
- Flow Cytometry
- Entrez GeneID:
- 2022
- Gene Name:
- ENG
- Gene Alias:
- CD105,END,FLJ41744,HHT1,ORW,ORW1
- Gene Description:
- endoglin
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- CD105 antigen,OTTHUMP00000022221,Osler-Rendu-Weber syndrome 1
- Related Disease
- Aneurysm
- Aneurysm, Ruptured
- Arteriovenous Malformations
- Cardiovascular Diseases
- Central Nervous System Vascular Malformations
- Chromosome Aberrations
- Diabetes Mellitus, Type 2
- Edema
- Epistaxis
- Genetic Predisposition to Disease
- Heart Defects, Congenital
- Hypertension, Pulmonary
- Intracranial Aneurysm
- Intracranial Arteriovenous Malformations
- Kidney Failure, Chronic
- Liver Cirrhosis
- Liver Diseases
- Lung Neoplasms
- Pre-Eclampsia