PPP1R1B MaxPab mouse polyclonal antibody (B01)
产品名称： PPP1R1B MaxPab mouse polyclonal antibody (B01)
英文名称： PPP1R1B MaxPab mouse polyclonal antibody (B01)
产品编号： H00084152-B01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse polyclonal antibody raised against a full-length human PPP1R1B protein.
- Immunogen:
- PPP1R1B (NP_115568.2, 1 a.a. ~ 204 a.a) full-length human protein.
- Sequence:
- MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHLKSKRPNPCAYTPPSLKAVQRIAESHLQSISNLNENQASEEEDELGELRELGYPREEDEEEEEDDEEEEEEEDSQAEVLKVIRQSAGQKTTCGQGLEGPWERPPPLDESERDGGSEDQVEDPALSEPGEEPQRPSPSEPGT
- Host:
- Mouse
- Reactivity:
- Human
- Storage Buffer:
- No additive
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody reactive against mammalian transfected lysate.
- Note:
- For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
- MSDS:
Download
- Applications
- Western Blot (Transfected lysate)
- Western Blot analysis of PPP1R1B expression in transfected 293T cell line (H00084152-T01) by PPP1R1B MaxPab polyclonal antibody.
Lane 1: PPP1R1B transfected lysate(22.44 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Entrez GeneID:
- 84152
- GeneBank Accession#:
- NM_032192.2
- Protein Accession#:
- NP_115568.2
- Gene Name:
- PPP1R1B
- Gene Alias:
- DARPP-32,DARPP32,FLJ20940
- Gene Description:
- protein phosphatase 1, regulatory (inhibitor) subunit 1B
- Omim ID:
- 604399
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons (Ouimet and Greengard, 1990 [PubMed 2191086]) that also express dopamine D1 receptors (Walaas and Greengard, 1984 [PubMed 6319627]). The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions (Halpain et al., 1990 [PubMed 2153935]). Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 (Walaas and Greengard, 1984 [PubMed 6319627]); phosphorylated DARPP32 is a potent protein phosphatase-1 (see MIM 176875) inhibitor (Hemmings et al., 1984 [PubMed 6087160]). NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32 (Halpain et al., 1990 [PubMed 2153935]).[supplied by OMIM
- Other Designations:
- OTTHUMP00000164276,dopamine and cAMP regulated phosphoprotein,dopamine and cAMP-regulated neuronal phosphoprotein 32,protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)
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