SNAI2 polyclonal antibody
产品名称： SNAI2 polyclonal antibody
英文名称： SNAI2 polyclonal antibody
产品编号： PAB1923
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SNAI2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to internal region of human SNAI2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha.
Park SH, Cheung LW, Wong AS, Leung PC.Mol Endocrinol. 2008 Sep;22(9):2085-98. Epub 2008 Jun 11.
- 2.
- Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype.
Belguise K, Guo S, Yang S, Rogers AE, Seldin DC, Sherr DH, Sonenshein GE.Cancer Res. 2007 Dec 15;67(24):11742-50.
- 3.
- Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium.
Kato N, Shimmura S, Kawakita T, Miyashita H, Ogawa Y, Yoshida S, Higa K, Okano H, Tsubota K.Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1511-7.
- Applications
- Western Blot (Tissue lysate)
- SNAI2 polyclonal antibody (Cat # PAB1923) is used in Western blot to detect SNAI2 in mouse heart tissue lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with SNAI2 polyclonal antibody (Cat # PAB1923) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 6591
- Protein Accession#:
- NP_003059;O43623
- Gene Name:
- SNAI2
- Gene Alias:
- MGC10182,SLUG,SLUGH1,WS2D
- Gene Description:
- snail homolog 2 (Drosophila)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq
- Other Designations:
- OTTHUMP00000195093,neural crest transcription factor SLUG,slug (chicken homolog), zinc finger protein,slug homolog, zinc finger protein,snail 2
- Gene Pathway
- Related Disease