CBL polyclonal antibody
产品名称： CBL polyclonal antibody
英文名称： CBL polyclonal antibody
产品编号： PAB12976
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CBL.
- Immunogen:
- A synthetic peptide corresponding to C-terminus 14 amino acids of human CBL.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The Cbl family proteins: ring leaders in regulation of cell signaling.
Swaminathan G, Tsygankov AY.J Cell Physiol. 2006 Oct;209(1):21-43.
- 2.
- c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.
Thien CB, Langdon WY.Biochem J. 2005 Oct 15;391(Pt 2):153-66.
- 3.
- Themes and variations on ubiquitylation.
Weissman AM.Nat Rev Mol Cell Biol. 2001 Mar;2(3):169-78.
- Entrez GeneID:
- 867
- Protein Accession#:
- P22681
- Gene Name:
- CBL
- Gene Alias:
- C-CBL,CBL2,RNF55
- Gene Description:
- Cas-Br-M (murine) ecotropic retroviral transforming sequence
- Omim ID:
- 165360
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq
- Other Designations:
- oncogene CBL2