IL4 (Human) Recombinant Protein-蛋白质/抗原/多肽-试剂-生物在线

产品名称： IL4 (Human) Recombinant Protein

英文名称： IL4 (Human) Recombinant Protein

产品编号： P4558

产品价格： 0

产品产地：台湾

品牌商标： Abnova

更新时间： null

使用范围： null

亚诺法生技股份有限公司（Abnova)

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Sequence:
MHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS

Activity:
The activity is determined by the proliferation of MC-9 cells. The expected ED50 for this effect is 110-160 pg/mL.

Storage Instruction:
Store at -20°C on dry atmosphere.
After reconstitution with sterilized water, store at -20°C.
Aliquot to avoid repeated freezing and thawing.

Quality Control Testing:
1 ug/lane in 4-20% Tris-Glycine gel Stained with Coomassie Blue

Lane 1: non-reducing conditions
Lane 2: reducing conditions

Note:
Result of activity analysis
MC-9 cells were cultured with 0 to 2 ng/mL human IL4. Cell proliferation was measured and the linear portion of the curve was us used to calculate the ED50.

Gene Summary:
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq

Other Designations:
B cell growth factor 1,B_cell stimulatory factor 1,lymphocyte stimulatory factor 1