1) Cat. No.: TRC-E555800; 2) Chemical Name: ENMD 547; 3) CAS No.: 644961-61-5; 4) Mol. Formula: C15H30BrN3O2; 5) Mol. Weight: 364.32; 6) Packing Size: 20mg / 200mg; 7) Appearence: N/A; 8) Application Notes: A selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model.; 9) Synonym: 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone Hydrobromide; 1-(6-Amino-1-oxohexyl)-4-(3-methyl-1-oxobutyl)piperazine Monohydrobromide; ; 10) Solubility: ; 11) Storage condition: ; 12) References: Kelso, E.B., et al.: J. Pharmacol. Exp. Ther., 316, 1017 (2006), Kelso, E.B., et al.: Arthritis Rheum., 56, 765 (2007),