AML1/ETO DY Translocation FISH Probe
产品名称： AML1/ETO DY Translocation FISH Probe
英文名称： AML1/ETO DY Translocation FISH Probe
产品编号： FT0003
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Labeled FISH probes for identification of gene translocation using Fluorescent In Situ Hybridization Technique. (Technology)
- Storage Instruction:
- Store at 4°C in the dark.
- Quality Control Testing:
- Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
- Supplied Product:
- DAPI Counterstain (1500 ng/mL ) 250 uL
- Note:
Hybridization position of the probes on the chromosome.-
- Probe 1:
Size:
Fluorophore:
Location: - AML1
Approximately 1340kb
FITC
21q22.12
- Probe 2:
Size:
Fluorophore:
Location: - ETO
Approximately 1110kb
Texas Red
8q21.3
- Regulation Status:
- For research use only (RUO)
- Applications
- Fluorescent In Situ Hybridization (Cell)
- Protocol Download
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Human lymph node (FFPE) stained with AML1/ETO DY Translocation FISH Probe. Human lymph node cancer showed no AML1/ETO DY Translocation.
- Protocol Download
- Application Image
- Fluorescent In Situ Hybridization (Cell)
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Entrez GeneID:
- 861
- Gene Name:
- RUNX1
- Gene Alias:
- AML1,AML1-EVI-1,AMLCR1,CBFA2,EVI-1,PEBP2aB
- Gene Description:
- runt-related transcription factor 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- AML1-EVI-1 fusion protein,acute myeloid leukemia 1,aml1 oncogene,core-binding factor, runt domain, alpha subunit 2
- Entrez GeneID:
- 862
- Gene Name:
- RUNX1T1
- Gene Alias:
- AML1T1,CBFA2T1,CDR,ETO,MGC2796,MTG8,MTG8b,ZMYND2
- Gene Description:
- runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
- Omim ID:
- 133435
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- acute myelogenous leukemia 1 translocation 1 protein,acute myelogenous leukemia 1 translocation 1, cyclin-D related,core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related,eight twenty one protein,myeloid translocation gene