Product: Anti-IRAK2 (C2), polyclonal
Cat. No.: PC-044 (100 μg)
Background:
The pro-inflammatory cytokine IL-1 induces
cellular response through two subunits of its
receptor, IL-1 receptor I (IL-1RI) and IL-1
receptor accessory protein (IL-1RAcP). IL-1
receptor-associated kinase (IRAK) mediates
activation of NF-kb, which is a pivotal
transcription factor mediating inflammatory and
immune response. A novel member in the
IRAK/Pelle family was recently identified and
designated IRAK2. Both IRAK and IRAK2 recruit
to the subunits of the IL-1R complex after IL-1
binding and lead to NF-kb activation. IRAKs also
associate with Toll like receptor (TLR) and the
dominant negative mutants of IRAKs inhibit
LPS-induced NF-kB activation. Members in
IRAK/Pelle family play a central role in IL-1R
and TLR mediated inflammatory response.
IRAK2 is expressed in a variety of human
tissues.
Specificity:
Binds IRAK2. Anti-IRAK2 has no cross response
to IRAK.
Species Reactivity:
Human, other species not tested.
Ig Isotype:
Rabbit IgG
Immunogen:
A peptide corresponding to amino acid 546 to
564 of human IRAK2.
Format:
Immunoaffinity chromatography purified IgG,
100 μg in 200 μL of PBS containing 0.02
sodium azide.
Storage:
Store at 4°C.
Applications and Suggested Dilutions:

Immunohistochemistry: Use at 2 μg/mL

Western blot: Use at a 1:500 to 1:1,000
dilution.
The optimal dilution for a specific application
should be determined by the researcher.
Limitations:
For in vitro research use only. Not for use in
diagnostics or in humans.
Warranty:
No warranties, expressed or implied, are made
regarding the use of this product. KAMIYA
BIOMEDICAL COMPANY is not liable for any
damage, personal injury, or economic loss
caused by this product.