PRAME抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
PRAME抗体

PRAME抗体

商家询价

产品名称： PRAME抗体

英文名称： PRAMEAntibody

产品编号： XY11438-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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 PRAME抗体Applications

In-house applications ELISA, WB, IP     Application not tested? Please see our Guarantee.
Species specificity Human; other species not tested.
Images
Prev1NextView more validation data
  • 11438-1-AP;A549 cellsA549 cells were subjected to SDS PAGE followed by western blot with 11438-1-AP( PRAME Antibody) at dilution of 1:300
  • 11438-1-AP;A549 cellsIP Result of anti-PRAME (IP:11438-1-AP, 3ug; Detection:11438-1-AP 1:300) with A549 cells lysate 2400ug.
Positive WB detected in A549 cells, HepG2 cells
Positive IP detected in A549 cells
Recommended dilution WB : 1:200-1:1000
IP : 1:200-1:1000
 PRAME抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen PRAME fusion protein ag1906 Full name Preferentially expressed antigen in melanoma
Calculated molecular
weight		 509aa,58 kDa Observed molecular 
weight		 58 kDa
GenBank accession 
number		 BC014074 Gene ID (NCBI) 23532
Gene symbol PRAME Synonyms MAPE, OIP 4, OIP4, Opa interacting protein 4, PRAME
Background PRAME抗体

The PRAME (preferentially expressed antigen of melanoma) gene was previously shown to be overexpressed in ovarian/primary peritoneal serous carcinoma compared with malignant mesothelioma using gene expression arrays. It is considered a melanocyte differentiation antigen which is overexpressed in both solid and hematologic tumors. In normal tissue, a very low level of PRAME expression is found in normal testis, adrenals, ovary and endometrium. A high level of PRAME expression has been reported for several solid tumors, including ovarian cancer, breast cancer, lung cancer and melanomas, medulloblastoma, sarcomas, head and neck cancers, neuroblastoma, renal cancer, and Wilms’ tumor. As a nuclear transcriptional repressor protein, PRAME binds to retinoic acid receptor a, thereby inhibiting retinoic acid induced differentiation, growth arrest, and apoptosis. PRAME抗体

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