FITC标记的8-羟基脱氧鸟苷抗体
产品名称： FITC标记的8-羟基脱氧鸟苷抗体
英文名称： Anti-8-OHdG/FITC
产品编号： HZ-1278R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-8-OHdG/FITC Conjugated antibody
FITC标记的8-羟基脱氧鸟苷抗体
| 英文名称 | Anti-8-OHdG/FITC |
| 中文名称 | FITC标记的8-羟基脱氧鸟苷抗体 |
| 别 名 | 8 Hydroxyguanosine; 8-Hydroxy-2'-deoxyguanosine; 8-Hydroxydeoxyguanosine; 8 hydroxy 2’ deoxyguanosine; 8 hydroxyguanine; 8 hydroxyguanosine; 8 OHG; 8-OHG; 8OG; 8OHdG; 8OHG; 8 Oxoguanine; 8 hydroxyguanine; 8 Oxo 7,8 dihydroguanine; 8 oxo Gua; 8 oxoG. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 药物与化合物抗体 |
| 研究领域 | 肿瘤 细胞生物 免疫学 染色质和核信号 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Rat, 8-OHdG |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 0.283kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated to 8-OHdG |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: 8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease. Function: Oxoguanine 8 (8-Oxoguanine) is a mutagenic oxidative damage product of guanine. Guanine is the main target for reactive oxygen species in DNA, with 8-oxoguanine being the most frequent base lesion. Thus formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1. Subcellular Location: Nuclear Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 药物 化合物抗体 8-羟基脱氧鸟苷是活性氧自由基(ROS)引起DNA氧化损伤修饰产物之一,其生成原因很多,主要是电离辐射、化学致癌物代谢活化及细胞正常新陈代谢过程产生大量ROS直接攻击DNA中的鸟嘌呤(dG),使脱氧鸟苷氧化为8-OHdG。目前已成为DNA氧化损伤中最常采用的生物标志物 |
8-羟基脱氧鸟苷(8OHdG)是一种修饰的碱基，在DNA中由于作为有氧代谢的副产物和中间体以及在氧化应激期间形成的羟基自由基的攻击而发生。越来越多的证据表明，自由基反应参与了最终导致人类多种疾病的生物分子的损伤，如动脉粥样硬化、大脑和心脏缺血-再灌注损伤、癌症、类风湿性关节炎、炎症、糖尿病、衰老等。ND神经退行性疾病，如阿尔茨海默病。